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GEO help: Mouse over screen elements for information. |
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Status |
Public on Apr 29, 2020 |
Title |
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We observed changes in protein levels of EZH2, TRIM24, p53, and a substantial number of KRAB-ZF proteins in MCF7 cells upon introducing a peptide fragment containing the KRAB domain.
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Overall design |
mRNA profiles of MCF7 cells expressing Krab domain, knockdown of TRIM28, and Vector alone, sh scrambled control were generated using deep sequencing, in duplicate
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Contributor(s) |
Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X |
Citation(s) |
32743551 |
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Submission date |
Mar 11, 2020 |
Last update date |
Aug 07, 2020 |
Contact name |
Janani Kumar |
E-mail(s) |
jkumar@mdanderson.org
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Organization name |
MD Anderson Cancer Center
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Street address |
1515 Holcombe Blvd
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City |
Houston |
State/province |
TX |
ZIP/Postal code |
77030 |
Country |
USA |
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Platforms (1) |
GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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Samples (10)
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Relations |
BioProject |
PRJNA611924 |
SRA |
SRP252344 |
Supplementary file |
Size |
Download |
File type/resource |
GSE146769_RAW.tar |
2.4 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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