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Series GSE146661 Query DataSets for GSE146661
Status Public on Jun 29, 2020
Title Expression data from Patient-derived tumor models (PDX) establish from bone metastases and match human breast primary tumor.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Bone is the most common metastatic site in ER+ patients, however bone metastases are technically challenging to biopsy and analyse. Difficulties concern both tumour tissue acquisition and techniques for analysis and RNA extractions. Patient-derived xenografts (PDX) of BC bone metastases have not been reported yet. For the first time we established PDX models from bone metastatic biopsies of patients progressing on ET and treated by vertebroplasty. PDX models were analysed at transcriptomic level and compared to patient’s early primary tumours to identify new therapeutic targets associated with endocrine resistance in the metastatic setting.
Identification of activated signalling pathways in bone metastasis by comparative transcriptomic analyses of the bone metastasis derived PDX compared to the patients' primary breast tumor.
Overall design Microarrays of 8 PDX of bone metastasis samples and 4 matched patients’ breast tumor samples. No replicate.
Contributor(s) Montaudon E, Marangoni E, Tariq Z
Citation(s) 32792481, 37452026
Submission date Mar 09, 2020
Last update date Sep 12, 2023
Contact name Elisabetta Marangoni
Organization name Institut Curie
Street address 26 rue d'Ulm
City Paris
ZIP/Postal code 75005
Country France
Platforms (1)
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (11)
GSM4403838 PDX of bone metastasis, patient 118
GSM4403839 Breast tumor, patient 118
GSM4403840 PDX of bone metastasis, patient 124
BioProject PRJNA611590

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Supplementary file Size Download File type/resource
GSE146661_RAW.tar 42.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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