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Series GSE146608 Query DataSets for GSE146608
Status Public on Oct 06, 2021
Title Epigenetic landscape of Mammalian Brain M1 by Single Nucleus Methylation Sequencing [MM_M1]
Organism Callithrix jacchus
Experiment type Methylation profiling by high throughput sequencing
Summary Illustrating the cellular architecture of the mammalian brain is critical to understanding its diverse functions and complex animal behaviors. Single nucleus methylation sequencing was applied to M1 regions of human and mouse brains. we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster.
Overall design Apply snmC-seq2 to brain M1 regions to identify epigenomic landcape of the adult human and marmoset brains
Contributor(s) Tian W, Liu H, Luo C, Bartlett A, Krienen FM, Hodge RD, Lucero J, Nery JR, Rivkin A, Aldridge A, Castanon R, Chen H, Niu S, Behrens MM, Feng G, Lein E, Ecker JR
Citation(s) 34616062
NIH grant(s)
Grant ID Grant title Affiliation Name
U01 MH121282 Epigenomic cell-type classification and regulatory element identification in the human brain THE SALK INSTITUTE FOR BIOLOGICAL STUDIES Joseph R Ecker
HHMI_Ecker_J Investigator Ecker, Joseph R. Joseph R. Ecker
Submission date Mar 08, 2020
Last update date Jan 05, 2022
Contact name Joseph R Ecker
Phone 8584534100
Organization name HHMI-Salk-Institute
Department Genomic Analysis Laboratory
Lab Ecker lab
Street address 10010 North Torrey Pines Road
City La Jolla
State/province CA
ZIP/Postal code 92037
Country USA
Platforms (1)
GPL28240 Illumina NovaSeq 6000 (Callithrix jacchus)
Samples (3047)
GSM4396443 MM_M1_1_sample 0
GSM4396444 MM_M1_1_sample 1
GSM4396445 MM_M1_1_sample 2
BioProject PRJNA611534
SRA SRP252051

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Supplementary file Size Download File type/resource
GSE146608_RAW.tar 343.2 Gb (http)(custom) TAR (of TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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