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Series GSE145532 Query DataSets for GSE145532
Status Public on Apr 26, 2021
Title DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ATAC-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary G4s are nucleic acids secondary structures that form in the presence of four or more runs of gunanine. In vitro results suggested that G4s are involved in the regulation of both transcription and replication processes. In vitro results suggested that G4s are involved in the regulation of both transcription 6–10 and replication 11–13 processes allowed to demonstrate the actual folding of G4s in live cells, but also inserted them in a more biologically relevant context. . In the present work we mapped G4s in the chromatin of a WD-LPS cell line (93T449), we integrated the information of G4 folding with their chromatin context, the transcriptional level of the associated genes and compared the results with data obtained in a cell line of different origin (HaCaT).
 
Overall design Chromatin accessibility analysis in 93T449 (ATCC #CRL-3043) human liposarcoma cells.
 
Contributor(s) Lago S, Schotta G, Cernilogar FM, Richter SN
Citation(s) 34162892
Sara Lago, Filippo M. Cernilogar, Maryam Kazerani, Helena Domíniguez Moreno, Matteo Nadai, Gunnar Schotta, and Sara N. Richter. Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome. bioRxiv 2020.08.27.236778; doi:10.1101/2020.08.27.236778
Submission date Feb 19, 2020
Last update date Jul 14, 2021
Contact name Filippo M. Cernilogar
E-mail(s) filippo.cernilogar@med.uni-muenchen.de
Organization name LMU Munich
Department Biomedical Center
Street address Grosshaderner Strasse 9
City Planegg-Martinsried
ZIP/Postal code 82152
Country Germany
 
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (1)
GSM4320529 OmniATAC_93T449_NT_m1
This SubSeries is part of SuperSeries:
GSE145543 DNA G-quadruplexes modulate highly transcribed genes in human chromatin
Relations
BioProject PRJNA607520
SRA SRP250003

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Supplementary file Size Download File type/resource
GSE145532_RAW.tar 75.4 Mb (http)(custom) TAR (of BIGWIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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