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| Status |
Public on Jun 29, 2020 |
| Title |
Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (scRNA-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Differences in female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. The characterization of the mechanisms that drive differential neutrophil phenotypes between genders has been investigated. This provides new insights that distinct sex difference in neutrophil biology related to responses to type I IFNs, immunometabolism and maturation status that may have prominent functional and pathogenic implications. The transcriptome of neutrophils from healthy adult males and females was characterized using bulk RNASeq. The transcriptome of whole blood leukocytes was elucidated using scRNASeq.
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| Overall design |
The RNAseq dataset includes a total of 14 individual samples. The scRNASeq dataset includes a total of 7 individual samples. This study sought to characterize sex differences in neutrophil biology. Transcriptomic profiles of neutrophils from healthy adult males and females were characterized.
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| Contributor(s) |
Gupta S, Nakabo S, O'Neil L, Wigerblad G, Mistry P, Jiang K, Dell'Orso S, Sun HW, Kaplan MJ |
| Citation(s) |
32601182 |
| Submission date |
Feb 13, 2020 |
| Last update date |
Feb 22, 2023 |
| Contact name |
Mariana J. Kaplan |
| Organization name |
NIH/NIAMS
|
| Department |
Systemic Autoimmunity Branch
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| Lab |
Lupus Clinical Trials Unit
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| Street address |
9000 Rockville Pike
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE145231 |
Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism |
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| Relations |
| BioProject |
PRJNA606472 |
| SRA |
SRP248939 |
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