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Series GSE145230 Query DataSets for GSE145230
Status Public on Jun 29, 2020
Title Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (scRNA-seq)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Differences in female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. The characterization of the mechanisms that drive differential neutrophil phenotypes between genders has been investigated. This provides new insights that distinct sex difference in neutrophil biology related to responses to type I IFNs, immunometabolism and maturation status that may have prominent functional and pathogenic implications. The transcriptome of neutrophils from healthy adult males and females was characterized using bulk RNASeq. The transcriptome of whole blood leukocytes was elucidated using scRNASeq.
Overall design The RNAseq dataset includes a total of 14 individual samples. The scRNASeq dataset includes a total of 7 individual samples. This study sought to characterize sex differences in neutrophil biology. Transcriptomic profiles of neutrophils from healthy adult males and females were characterized.
Contributor(s) Gupta S, Nakabo S, O'Neil L, Wigerblad G, Mistry P, Jiang K, Dell'Orso S, Sun HW, Kaplan MJ
Citation(s) 32601182
Submission date Feb 13, 2020
Last update date Feb 22, 2023
Contact name Mariana J. Kaplan
Organization name NIH/NIAMS
Department Systemic Autoimmunity Branch
Lab Lupus Clinical Trials Unit
Street address 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (7)
GSM4308702 scRNA_Male_WBL_01
GSM4308703 scRNA_Male_WBL_02
GSM4308704 scRNA_Male_WBL_03
This SubSeries is part of SuperSeries:
GSE145231 Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism
BioProject PRJNA606472
SRA SRP248939

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145230_RAW.tar 304.5 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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