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| Status |
Public on Jun 04, 2020 |
| Title |
Roles of Mafb and c-Maf in MGE-derived pallial interneuron development and maturation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We utilized single-cell RNA-sequencing to identify candidate genetic targets of Mafb and c-Maf in the MGE-lineage using Nkx2.1-Cre generated neonatal wildtype (WT) and conditional Mafb/c-Maf double deletion mutant (cDKO) animals. We identified genes that likely contribute to Maf cDKO's phenotypes, which include preferential parvalbumin interneuron loss, overproduction of hippocampal interneurons and neurite outgrowth defects.
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| Overall design |
Examination of differentially expressed genes between Nkx2.1-Cre generated WT and Maf cDKO at P0; We focused on the MGE-lineage interneuron subtype.
>>>Raw data are not available due to file corruption<<<
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| Contributor(s) |
Pai EL, Rubenstein J |
| Citation(s) |
32452758 |
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| Submission date |
Jan 24, 2020 |
| Last update date |
Jun 16, 2020 |
| Contact name |
Ling-Lin Pai |
| Organization name |
UCSF
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| Department |
Psychiatry
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| Lab |
Rubenstein
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| Street address |
1550 4th Street
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA603077 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE144222_RAW.tar |
2.6 Gb |
(http)(custom) |
TAR (of H5, HTML, MTX, TSV) |
| GSE144222_molecule_info_file_contents.txt.gz |
1.0 Kb |
(ftp)(http) |
TXT |
| Processed data provided as supplementary file |
| Raw data not provided for this record |
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