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Series GSE143979 Query DataSets for GSE143979
Status Public on Jan 22, 2020
Title Skeletal muscle regeneration is compromised in advanced diabetic peripheral neuropathy
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary DPN muscle exhibits features of degeneration with attempted regeneration. In the most severely pathological muscle samples, regeneration appears to be stymied and our data suggest that this may be partly due to intrinsic dysfunction of the satellite cell pool in addition to extrinsic structural pathology (e.g. nerve damage).
Overall design Biopsies were acquired from two muscles in individuals with and without diabetic neuropathy undergoing below knee amputation surgery. Biopsies were subdivided for histological analysis, transcriptional profiling and satellite cell isolation and culture.

DPN: diabetic peripheral neuropathy
MNC: metabolically normal control
Contributor(s) Meyer GA, Bohnert KL, Gontarz P, Zhang B
Citation(s) 32059624
Submission date Jan 21, 2020
Last update date May 29, 2020
Contact name Bo Zhang
Phone 1-314-362-4757
Organization name Washington University School of Medicine
Department Developmental Biology
Street address 660 S. Euclid Avenue
City Saint Louis
State/province MO
ZIP/Postal code 63110
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (15)
GSM4277572 MB10 AH
GSM4277573 MB12 MG
GSM4277574 MB01 MG
BioProject PRJNA602424
SRA SRP243666

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Supplementary file Size Download File type/resource
GSE143979_merged_gene_name_expression.txt.gz 872.3 Kb (ftp)(http) TXT
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Processed data are available on Series record

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