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Series GSE14368 Query DataSets for GSE14368
Status Public on Dec 01, 2012
Title The anti-inflammatory IL-1 receptor antagonist (IL-1ra) protects against the development of islet autoimmunity.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Through gene expression profiling in cultured lymphocytes and PBMCs from a large set of T1D patients and controls, we demonstrate that IL-1ra may protect against the development of islet autoimmunity and T1D through down-regulating a large number of inflammatory genes and pathways.

Keywords: autoimmunity; IL-1Ra;Type 1 diabetes (T1D)
 
Overall design To elucidate the molecular mechanism underlying the action of IL-1ra, we profiled gene expression in peripheral blood mononuclear cells (PBMC) cultured with sera from low or high IL-1ra subjects. To avoid potential heterogeneity in responder cells from different subjects, PBMCs from one healthy donor were cultured for six hours with 20% of sera from six subjects with low IL-1ra and six subjects with high IL-1ra. Gene expression in the cultured cells was analyzed with the Illumina HumanRef-8 v3.0 beadchips
 
Contributor(s) Purohit S, Podolsky R, Jin Y, Sharma A, Yang P, Wang H, Hopkins D, Steed L, Wang M, Zhi W, Bode B, Anderson S, Reed J, Steed D, Huang Y, Nechtman J, Miller E, Pederson J, Schatz D, Muir A, McIndoe RA, Barriga K, Eisenbarth G, Rewers M, She J
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Submission date Jan 09, 2009
Last update date Mar 20, 2017
Contact name Jin-Xiong She
E-mail(s) jshe@gru.edu
Phone 706-721-3410
Fax 706-721-3688
URL http://www.cbgm.mcg.edu/
Organization name Medical College of Georgia
Department Center for Biotechnology and Genomic Medicine
Street address 1120 15th Street, CA4124
City Augusta
State/province GA
ZIP/Postal code 30912-2400
Country USA
 
Platforms (1)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
Samples (12)
GSM359315 Serum_AbNH_8058
GSM359316 Serum_T1DL_7523
GSM359317 Serum_AbNL_6722
Relations
BioProject PRJNA111409

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE14368_RAW.tar 3.9 Mb (http)(custom) TAR
GSE14368_raw_datamatrix.txt 6.2 Mb (ftp)(http) TXT
Processed data included within Sample table

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