|
|
GEO help: Mouse over screen elements for information. |
|
Status |
Public on Dec 01, 2012 |
Title |
The anti-inflammatory IL-1 receptor antagonist (IL-1ra) protects against the development of islet autoimmunity. |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
|
Summary |
Through gene expression profiling in cultured lymphocytes and PBMCs from a large set of T1D patients and controls, we demonstrate that IL-1ra may protect against the development of islet autoimmunity and T1D through down-regulating a large number of inflammatory genes and pathways.
Keywords: autoimmunity; IL-1Ra;Type 1 diabetes (T1D)
|
|
|
Overall design |
To elucidate the molecular mechanism underlying the action of IL-1ra, we profiled gene expression in peripheral blood mononuclear cells (PBMC) cultured with sera from low or high IL-1ra subjects. To avoid potential heterogeneity in responder cells from different subjects, PBMCs from one healthy donor were cultured for six hours with 20% of sera from six subjects with low IL-1ra and six subjects with high IL-1ra. Gene expression in the cultured cells was analyzed with the Illumina HumanRef-8 v3.0 beadchips
|
|
|
Contributor(s) |
Purohit S, Podolsky R, Jin Y, Sharma A, Yang P, Wang H, Hopkins D, Steed L, Wang M, Zhi W, Bode B, Anderson S, Reed J, Steed D, Huang Y, Nechtman J, Miller E, Pederson J, Schatz D, Muir A, McIndoe RA, Barriga K, Eisenbarth G, Rewers M, She J |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
Submission date |
Jan 09, 2009 |
Last update date |
Mar 20, 2017 |
Contact name |
Jin-Xiong She |
E-mail(s) |
jshe@gru.edu
|
Phone |
706-721-3410
|
Fax |
706-721-3688
|
URL |
http://www.cbgm.mcg.edu/
|
Organization name |
Medical College of Georgia
|
Department |
Center for Biotechnology and Genomic Medicine
|
Street address |
1120 15th Street, CA4124
|
City |
Augusta |
State/province |
GA |
ZIP/Postal code |
30912-2400 |
Country |
USA |
|
|
Platforms (1) |
GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
Samples (12)
|
|
Relations |
BioProject |
PRJNA111409 |
Supplementary file |
Size |
Download |
File type/resource |
GSE14368_RAW.tar |
3.9 Mb |
(http)(custom) |
TAR |
GSE14368_raw_datamatrix.txt |
6.2 Mb |
(ftp)(http) |
TXT |
Processed data included within Sample table |
|
|
|
|
|