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Series GSE143355 Query DataSets for GSE143355
Status Public on May 29, 2020
Title Effect of IL-6 deficiency on gene expression in cell types of control and HD mouse striatum
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Huntington’s disease (HD) is an incurable neurodegenerative disorder that is caused by CAG trinucleotide expansions in the huntingtin gene. However, the exact molecular and cellular mechanisms underlying the pathogenesis of HD are still not well understood. Immune signaling has been hypothesized to contribute to HD pathogenesis. In this study, we used single-nucleus RNA sequencing (snRNA-seq) to access the transcriptional profiles of striatal cell types in control and R6/2 HD model mice that either had normal levels of, or were deficient for, the cytokine interleukin-6 (IL-6). Our results provide insights into the gene expression programs that are under the control of this important immune regulator in both a normal and HD model context.
Overall design Single-cell profiling of Il6 knock-out spiny projection neurons in R62 mouse model of HD.
Contributor(s) Pineda SS, Heiman M
Citation(s) 32448329
Submission date Jan 09, 2020
Last update date May 31, 2020
Contact name Myriam Heiman
Organization name Massachusetts Institute of Technology
Department Brain and Cognitive Sciences
Lab Heiman
Street address 77 Massachusetts Ave., Bldg 46-4285
City Cambridge
State/province Massachusetts
ZIP/Postal code 02139
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM4257550 WT/KO_rep1
GSM4257551 WT/KO_rep2
GSM4257552 WT/KO_rep3
BioProject PRJNA600211
SRA SRP240898

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE143355_RAW.tar 1.5 Gb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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