|
| Status |
Public on Jan 01, 2021 |
| Title |
Adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Beta-adrenergic stimulation stabilizes ERK3, resulting in the formation of a complex with MK5 and thereby driving lipolysis. A downstream target of the complex is FOXO1, which controls expression of the lipolytic enzyme ATGL. Deletion of ERK3 in mouse adipocytes inhibits lipolysis, but elevates energy dissipation.
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| |
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| Overall design |
Global gene expression changes in differentiated adipocytes of mice after knockdown of ERK3.
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| |
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| Contributor(s) |
El-Merahbi R, Trujillo Viera J, Loza Valdes A, Löffler MC, Reuter S, Karwen T, Mayer AE, Ade CP, Erk M, Eilers M, Sumara G |
| Citation(s) |
32139423 |
| |
| Submission date |
Dec 20, 2019 |
| Last update date |
Jan 13, 2021 |
| Contact name |
Carsten P Ade |
| Organization name |
University of Wuerzburg
|
| Department |
Lehrstuhl Biochemie und Molekularbiologie
|
| Lab |
AG Martin Eilers
|
| Street address |
Am Hubland
|
| City |
Wuerzburg |
| ZIP/Postal code |
97074 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (8)
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|
| Relations |
| BioProject |
PRJNA597001 |
| SRA |
SRP238353 |
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