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| Status |
Public on Dec 05, 2021 |
| Title |
Tumor-derived exosomal miR-181a-5p activates hepatic stellate cells to promote liver metastasis of colorectal cancer |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
A previous study suggested that the expression of miR181a-5p was higher in CRC tissues, but whether CRC cell-derived exosomes regulate the activation of HSCs through secreting miR181a-5p and promoting CRLM warrants further investigation.
We compared the miRNA expression profiles between exosomes from highly metastatic CRC cells (RKO and SW620) and those from weakly-metastatic CRC cells (HT29 and SW480).
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| Overall design |
The Agilent Human miRNA Microarray Kit, Release 21.0, 8x60K (DesignID: 070156) experiment and data analysis were performed in exosomes from two highly metastatic CRC cells (RKO and SW620) and two weakly-metastatic CRC cells (HT29 and SW480). The microarray contains 2570 probes for mature miRNA. Three independent experiments were performed.
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| Contributor(s) |
Zhao S, Mi Y, Zheng B, Wei P, Gu Y, Xu Y, Cai S, Li X, Li D |
| Citation(s) |
35041299 |
| |
| Submission date |
Dec 13, 2019 |
| Last update date |
Feb 02, 2022 |
| Contact name |
Senlin Zhao |
| E-mail(s) |
sunshinezsl1989@hotmail.com
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| Phone |
18017312693
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| Organization name |
Cancer Hospital, Fudan University
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| Department |
Colorectal Surgery
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| Street address |
270 Dong An Road
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL24741 |
Agilent-070156 Human_miRNA_V21.0_Microarray 046064 (gene name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA595546 |
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