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Series GSE141861 Query DataSets for GSE141861
Status Public on Jun 14, 2021
Title Secondary Resistance to Anti-EGFR Therapy by Transcriptional Reprogramming in Patient-Derived Colorectal Cancer Models
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary 3' RNA-seq of patient derived colon cancer xenograft models (N=10) showing initial disease control under cetuximab treatment were collected. All xenograft models were wildtype for KRAS, NRAS, BRAF and PIK3CA. All mice were treated with cetuximab (Merck Serono) by intra peritoneal (i.p.) injection twice per week and dosed at 25mg/kg to establish response characteristics. Tumors were chronically treated to establish cetuximab secondary resistant tumors .
Overall design Three conditions were generated for comparisons: untreated control (K), 5 days cetuximab treatment (5dC) while pdx tumors were responsive to cetuximab and cetuximab secondary resistant tumors (C) following chronic cetuximab treatment.
Contributor(s) Hahn SA, Admard J
Citation(s) 34271981
Submission date Dec 11, 2019
Last update date Jul 27, 2021
Contact name Jakob Admard
Organization name Universitätsklinikum Tübingen
Department Institut für Medizinische Genetik und Angewandte Genomik
Street address Calwerstr. 7
City Tübingen
ZIP/Postal code 72076
Country Germany
Platforms (2)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
GPL25526 Illumina NovaSeq 6000 (Homo sapiens; Mus musculus)
Samples (50)
GSM4214799 BoC10 C2
GSM4214800 BoC20 5dC1
GSM4214801 BoC10F 5dC1
BioProject PRJNA594974
SRA SRP236891

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141861_RAW.tar 6.1 Mb (http)(custom) TAR (of TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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