GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE141456 Query DataSets for GSE141456
Status Public on Jun 29, 2020
Title Photothermal Modulation of Human Stem Cells Using Light-responsive 2D Nanomaterials
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photo-responsive at near-infrared wavelengths (NIR). Here, we demonstrate for the first time the ability of 2D MoS2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2 with human stem cells is investigated using whole transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence by NIR stimulation of MoS2 on integrins, cellular migration and wound healing. Overall, the combination of MoS2 and NIR light may provide new approach to control and regulate cellular migration and functions.
Overall design Examination of effect of MoS2 and NIR on human mesenchymal stem cells (hMSCs)
Contributor(s) Jake CK, Kanwar SA, Irtisha S, Akhilesh GK
Citation(s) 32461372
Submission date Dec 04, 2019
Last update date Jun 29, 2020
Contact name Irtisha Singh
Organization name Texas A&M Health Science Center
Street address 8447 Riverside Pkwy Medical Research and Education Building II
City Bryan
State/province TX
ZIP/Postal code 77807
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (8)
GSM4203372 hMSCs 1
GSM4203373 hMSCs 2
GSM4203374 hMSCs MoS2 1
BioProject PRJNA593516
SRA SRP234710

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141456_rpkm.txt.gz 764.7 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap