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Series GSE141031 Query DataSets for GSE141031
Status Public on Mar 01, 2020
Title Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation.  Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice.
Overall design Using scRNAseq to compare the gene expression profiles of smooth muscle cells beteewn ApoE mice and SMC specific TGFbR2 KO Apoe mice fed with high fat diet
Contributor(s) Simons M, Chen P
Citation(s) 32243809
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 HL135582 Endothelial-to-mesenchyma transition and atherosclerosis YALE UNIVERSITY Michael Simons
Submission date Nov 26, 2019
Last update date Apr 08, 2020
Contact name Michael Simons
Organization name Yale University
Department Department: Internal Medicine Cardiology
Lab Yale Cardiovascular Research Center
Street address 3oo George St, Suite 773
City New Haven
State/province CT
ZIP/Postal code 06511
Country USA
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (8)
GSM4192692 Apoe ND
GSM4192693 Apoe 1M HFD
GSM4192694 Apoe 2M HFD
This SubSeries is part of SuperSeries:
GSE141032 Smooth muscle cell reprogramming in aortic aneurysms
BioProject PRJNA591808
SRA SRP233287

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141031_apoe_0M_1M_2M_4M_combined_count_tmm_relaxed_filter_noApoeTgfbr.csv.gz 29.0 Mb (ftp)(http) CSV
GSE141031_apoe_dko_0m_combined_count_tmm_relaxed_filter_noApoeTgfbr2.csv.gz 12.1 Mb (ftp)(http) CSV
GSE141031_apoe_dko_1m_combined_count_tmm_relaxed_filter_noApoeTgfbr2.csv.gz 12.5 Mb (ftp)(http) CSV
GSE141031_apoe_dko_2m_combined_count_tmm_relaxed_filter_noApoeTgfbr2.csv.gz 19.6 Mb (ftp)(http) CSV
GSE141031_apoe_dko_4m_combined_count_tmm_relaxed_filter_noApoeTgfbr2.csv.gz 12.4 Mb (ftp)(http) CSV
GSE141031_dko_0M_1M_2M_4M_combined_count_tmm_relaxed_filter_noApoeTgfbr.csv.gz 28.4 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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