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Series GSE141026 Query DataSets for GSE141026
Status Public on Jul 15, 2020
Title Inter-individual variability in lymphocyte stimulation and transcriptomic response predicts mycophenolic acid sensitivity in healthy volunteers
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Mycophenolic acid is an immunosuppressant commonly used to prevent renal transplant rejection and treat glomerulonephritis. Despite its widespread use, there is a clinical need to reduce solid-organ transplant rejection and improve rates of complete therapeutic response in autoimmunity. Single-cell RNA-sequencing (n=6) in lymphocytes was performed at baseline, post-stimulation, and post-mycophenolate treatment. This study identifies a polygenic transcriptomic signature in lymphocyte sub-populations predictive of mycophenolate response.
Overall design Lymphocytes were sequenced at baseline (after Ficoll Isolation), post-stimulation (antibodies to CD3/CD28), and post-MPA treatment (1 µg/mL).
Contributor(s) Eadon M, Collins K
Citation(s) 32415749
Submission date Nov 26, 2019
Last update date Jul 15, 2020
Contact name Kimberly S. Collins
Organization name Indiana University School of Medicine
Department Medicine
Lab Eadon
Street address 950 W Walnut Street E202
City Indianapolis
State/province IN
ZIP/Postal code 46202
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (18)
GSM4192571 BR-14: Baseline Resistant Individual 1 (Baseline.R1)
GSM4192572 BR-35: Baseline Resistant Individual 2 (Baseline.R2)
GSM4192573 BR-36: Baseline Resistant Individual 3 (Baseline.R3)
BioProject PRJNA591800
SRA SRP233284

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Supplementary file Size Download File type/resource
GSE141026_integrated.all0.8.edited.RDS.gz 4.8 Gb (ftp)(http) RDS
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