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Series GSE140763 Query DataSets for GSE140763
Status Public on Feb 04, 2020
Title CBX4 role in U2OS/MTX300
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown to participate in the polycomb repressive complex 1 (PRC1) and characterized as a transcriptional repressor. To identify the downstream target genes of CBX4 in osteosarcoma, we conducted the RNA-seq analysis of CBX4 overexpression or knockdown in osteosarcoma cell line U2OS/MTX300.
Overall design U2OS/MTX300 cells overexpressing CBX4 are compared to Vector, and shCBX4 are compared to shControl
Contributor(s) Kang T, Wang X
Citation(s) 32111827
Submission date Nov 21, 2019
Last update date Mar 09, 2020
Contact name Xin Wang
Phone +862087343182
Organization name Sun Yat-sen University Cancer Center
Street address Dongfengdong road 651
City Guang Zhou
State/province State...
ZIP/Postal code 020-87343182
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (5)
GSM4183313 U2OS/MTX300 reference cells
GSM4183314 U2OS/MTX300 cells overexpressing CBX4
GSM4183315 U2OS/MTX300 control shRNA cells
BioProject PRJNA590871
SRA SRP231137

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140763_WT_vs_Vector.txt.gz 1.5 Mb (ftp)(http) TXT
GSE140763_shCBX4_vs_shControl.txt.gz 4.0 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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