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Series GSE140731 Query DataSets for GSE140731
Status Public on Nov 21, 2019
Title Transcriptomic analysis of adhesive capsulitis of the shoulder
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We compared genes from tissue of patients with adhesive capsulitis (AC) with those having surgery for shoulder instability to determine potential biomarkers specific to AC through transcriptomic analysis. Our results presented increased expression of PDGFB, COL18A1 and MMP9 in patients with AC, while TNFA expression was reduced.
Overall design Tissue samples were collected from the anterior capsule and rotator interval during surgery. Total RNA was extracted and RNA-sequencing-based transcriptomics were performed. Bioinformatic analyses were carried out to identify biological processes and pathways enriched in this dataset. A number of genes deemed differentially expressed in RNA-sequencing analysis were validated using real time RT-PCR.
Contributor(s) Kamal N, McGee SL, Brown G, Beattie S, Eng K, Collier F, Gill S, Page R
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Submission date Nov 20, 2019
Last update date Nov 27, 2019
Contact name Nima Kamal
Organization name Deakin University
Department School of Medicine
Lab Molecular and Medical Research
Street address 75 Pigdons Rd
City Waurn Ponds
State/province VIC
ZIP/Postal code 3216
Country Australia
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (48)
GSM4182739 AD-CAB 1001
GSM4182740 AD-CAB 1002
GSM4182741 AD-CAB 1003
BioProject PRJNA590709
SRA SRP230798

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140731_NGS.csv.gz 2.1 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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