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Series GSE140720 Query DataSets for GSE140720
Status Public on Nov 19, 2021
Title Immunization with two heterotypic influenza hemagglutinins by time difference effectively produces broadly binding antibodies against heterotypic influenza virus
Organism Mus musculus
Experiment type Other
Summary Broadly protective antibodies against highly variable pathogens are very important for design of vaccines and therapeutics. We report that by administering two heterotypic influenza hemagglutinins (HAs) to mice by time difference, monoclonal antibodies can be obtained that bind strongly to both heterotypic influenza HAs. More interestingly, it was able to bind widely to the untreated subtype of HA.
Overall design Examination of antibodies produced when mice are immunized with two types of HA (H1 and H2).
Contributor(s) Watanabe T, Ohara O
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Submission date Nov 20, 2019
Last update date Nov 20, 2021
Contact name Takashi Watanabe
Organization name RIKEN
Street address 1-7-22, Suehiro, Tsurumi
City Yokohama
ZIP/Postal code 2300045
Country Japan
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (20)
GSM4182452 H2_PR8_G_p1_BCR-seq
GSM4182453 H2_PR8_K_p1_BCR-seq
GSM4182454 H2_PR8_G_p2_BCR-seq
BioProject PRJNA590668
SRA SRP230784

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140720_200818-1_summary.list.txt.gz 5.4 Kb (ftp)(http) TXT
GSE140720_RAW.tar 80.0 Kb (http)(custom) TAR (of FASTA)
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Raw data are available in SRA
Processed data provided as supplementary file

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