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Series GSE140707 Query DataSets for GSE140707
Status Public on Nov 21, 2019
Title Identifying a novel candidate diagnostic and prognostic biomarker SPRR3 for oral squamous cell carcinoma via mRNA Sequencing and Bioinformatics
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive malignancies among the numerous oral and maxillofacial malignancies. we collected three tumorous and adjacent tissues from OSCC sufferers, and we obtained differentially expressed genes (DEGs) via high throughput RNA sequence.
Overall design We obtained 229 DEGs between tumor and normal tissues. Function and pathway enrichment analyses for DEGs were conducted to find correlation between tumorigenesis status and differentially expressed genes.Protein interaction network and molecular complex detection were constructed to find meaningful modules. Two core modules were enriched in MCODE. The diagnostic and prognostic values of the candidate genes were analyzed, which provide evidence for the candidate genes as new tumor markers.
Contributor(s) Lu Y, Yang Z
Citation(s) 32596058
Submission date Nov 20, 2019
Last update date Jul 29, 2020
Contact name Lu Yu
Phone +86 15953147587
Organization name School and Hospital of Stomatology, Shandong University
Department Department of Implantology
Lab Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration
Street address No.44-1 Wenhua Road West
City Jinan
State/province Shandong
ZIP/Postal code 250012
Country China
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (6)
GSM4182317 tumor 1
GSM4182318 tumor 2
GSM4182319 tumor 3
BioProject PRJNA590628
SRA SRP230776

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140707_RAW.tar 8.4 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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