|
| Status |
Public on Feb 04, 2020 |
| Title |
In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice [Cut&Run] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
In most cancers, only a few genes are mutated at high frequencies, while the vast majority are mutated at low frequencies. The functions of these recurrent but infrequent ‘long-tail’ mutations remain largely elusive. Here, we develop in vivo CRISPR screens to assess the transforming potential of 484 long-tail genes in human Head and Neck Squamous Cell 5 Carcinoma (HNSCC).
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| |
|
| Overall design |
Differential Rbpj cut and run peaks for Ajuba WT vs. Knockout Cells.
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| |
|
| Contributor(s) |
Loganathan SK, Malik AA, Tsai R, Schramek D |
| Citation(s) |
32165588 |
| |
| Submission date |
Nov 15, 2019 |
| Last update date |
May 06, 2020 |
| Contact name |
Daniel Schramek |
| E-mail(s) |
schramek@lunenfeld.ca
|
| Organization name |
Lunenfeld- Tanenbaum Research Institute
|
| Lab |
Schramek Lab
|
| Street address |
600 University Ave, Room 1080
|
| City |
Toronto |
| State/province |
ON |
| ZIP/Postal code |
M5G 1X5 |
| Country |
Canada |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (5)
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| This SubSeries is part of SuperSeries: |
| GSE140497 |
In vivo CRISPR screens reveal NOTCH regulators suppressing Head and Neck Squamous Cell Carcinoma in mice |
|
| Relations |
| BioProject |
PRJNA589895 |
| SRA |
SRP230214 |
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