GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE139987 Query DataSets for GSE139987
Status Public on Jan 14, 2020
Title Altered expression of long non-coding and messenger RNAs in diabetic nephropathy following treatment with rosiglitazone
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Diabetic nephropathy (DN) is characterized by metabolic disorder and inflammation. However, the regulatory effects that long noncoding RNAs (lncRNAs) have on the pathogenesis of DN and on the efficacy of rosiglitazone treatment has yet to be clearly defined. Herein, we performed unbiased RNA sequencing to characterize the transcriptomic profiles in db/db diabetic mouse model with or without rosiglitazone treatment that served to improve the phenotypes of DN. Differential expression analysis revealed that those genes that had their expression restored following treatment with rosiglitazone are likely involved in protection against DN. Our data elucidate the novel renoprotective molecular mechanism of PPARĪ³ agonists and propose lncRNA targets for diabetic nephropathy treatment.
Overall design Diabetic (db/db) mice were randomly divided into two groups and treated with 20 mg/kg/day of rosiglitazone (dbR group) or with a vehicle (dbdb group) by gavage for 8 weeks (from 7-15 weeks of age), respectively. Db/m littermates (control group) were also treated with the vehicle. Total RNA from kidney cortex of each mouse was sequenced (3 replicates per group) on illumina HiSeq X Ten platform.
Contributor(s) Zhang L, Wang W
Citation(s) 32025515
Submission date Nov 05, 2019
Last update date Feb 10, 2020
Contact name Liwen Zhang
Organization name Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Street address 197 Ruijin Er Road
City Shanghai
ZIP/Postal code 200025
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (9)
GSM4151169 Control1
GSM4151170 Control2
GSM4151171 Control3
BioProject PRJNA588269
SRA SRP229108

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139987_RAW.tar 7.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap