GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE139943 Query DataSets for GSE139943
Status Public on Oct 30, 2020
Title Cystic Fibrosis Keystone Species
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary This project shows that the use of antibiotics targeting gram-positive, anaerobic bacteria can improve patient's health by removing the main nutritional sources of classic pathogens. These antibiotics, traditionally not used in CF therapy, target anaerobes that efficiently degrade mucus providing metabolic products that feed and stimulate the expression of virulence factors in Pseudomonas. They work as keystone groups sustaining the stability of the entire microbial community, and their control drives a decrease in Pseudomonas abundance and virulence.
Overall design 9 transcriptomes from longitudinal sampling of the same patient.
Contributor(s) Silveira C
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 05, 2019
Last update date Nov 01, 2020
Contact name Cynthia Silveira
Organization name San Diego State University
Department Biology
Street address 5500 Campanile Dr, North Life Sciences 302
City San Diego
State/province CALIFORNIA
ZIP/Postal code 92182
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (9)
GSM4150367 CF146_day16_mt
GSM4150368 CF146_day21_mt
GSM4150369 CF146_day28_mt
BioProject PRJNA587705
SRA SRP228590

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139943_RAW.tar 10.0 Kb (http)(custom) TAR (of TAB)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap