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| Status |
Public on Nov 02, 2019 |
| Title |
Transcriptomics analysis of cortical astrocytes subjected to Rbpj-K deletion and stab-wound injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed single cell RNA-sequencing to investigate the molecular properties of Rbpj-K deleted astrocytes from the mouse somatosensory cortex. In the presence of a stab-wound injury, these cells undertake a neurogenic program, which can be analysed in the present dataset. The experiment encompassed cells from Rbpj-K-/- as well as wild type animals, and collected from injured or healthy cortices 3 wpi.
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| Overall design |
Examination of transcriptional changes occurring in cortical astrocytes isolated from the mouse cortex subjected to Rbpj-K deletion and stab-wound injury. Four samples were analyzed: WT x healthy; WT x injured; KO x healthy; KO x injured.
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| Contributor(s) |
Zamboni M, Frisén J |
| Citation(s) |
32758425 |
| Submission date |
Nov 01, 2019 |
| Last update date |
Aug 13, 2020 |
| Contact name |
Margherita Zamboni |
| E-mail(s) |
margherita.zamboni@ki.se
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| Organization name |
Karolinska Institutet
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| Department |
Cell and Molecular Biology
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| Lab |
Jonas Frisen
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| Street address |
Solnavägen 9
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| City |
Stockholm |
| ZIP/Postal code |
171 65 |
| Country |
Sweden |
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| Platforms (2) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA587138 |
| SRA |
SRP227978 |
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