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Series GSE139827 Query DataSets for GSE139827
Status Public on Dec 27, 2019
Title Single cell RNA sequencing for mouse femoral artery
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Rapid regeneration of smooth muscle after vascular injury is essential for maintaining proper artery function. The current view holds that pre-existing smooth muscle proliferate and expand in responding to vascular injury, contributing to virtually all new smooth muscle cells. Whether resident vascular stem cells for smooth muscle exist remains controversial and their putative functional role for artery repair and regeneration is elusive. Here we performed cell fate mapping and single cell RNA sequencing to identify Sca1+ vascular stem cells (VSCs) residing in the adventitial layer of artery wall.
Overall design To examine the cellular components of Sca1+ cells, individual cells were isolated from the femoral artery by enzymatic digestion and processed for single-cell RNA-sequencing technology.
Contributor(s) Zhou B, Gao D, Tang J, Li F
Citation(s) 31883835
Submission date Nov 01, 2019
Last update date Jan 03, 2020
Contact name Fei Li
Organization name Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Street address 320 Yue-Yang Road Shanghai
City Shanghai
ZIP/Postal code 200031
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (1)
GSM4147025 Femoral_artery (single-cell RNA-seq)
BioProject PRJNA587113
SRA SRP227940

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Supplementary file Size Download File type/resource
GSE139827_RAW.tar 16.1 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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