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Series GSE139657 Query DataSets for GSE139657
Status Public on Nov 29, 2019
Title Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design
Organism Adeno-associated virus
Experiment type Other
Summary An Adeno-Associated Virus capsid fitness landscape reveals a frameshifted viral gene and in vivo design principles, enabling machine-guided engineering.
 
Overall design Multi-mutants were synthsized using agilent chips, and cloned and transfected to mice, tissue samples from the liver were collected after 2 weeks.
 
Contributor(s) Ogden P, Kelsic E, Sinai S, Church G
Citation(s) 31780559
Submission date Oct 31, 2019
Last update date Feb 06, 2020
Contact name Pierce Ogden
E-mail(s) pierceogden@gmail.com
Organization name Harvard
Lab Church Lab
Street address 3 Blackfan Circle, CLSB 528/4C
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL27708 Illumina NextSeq 500 (Adeno-associated virus)
Samples (169)
GSM4145472 CMV_plasmid_0_p-a_GEN00105092
GSM4145473 CMV_plasmid_0_p-b_GEN00113847
GSM4145474 CMV_plasmid_0_p-c_GEN00113848
Relations
BioProject PRJNA586835
SRA SRP227810

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139657_AAV2VP1_Pos561_588_multi-mutants_LiverTropism.csv.gz 752.4 Kb (ftp)(http) CSV
GSE139657_RAW.tar 207.2 Mb (http)(custom) TAR (of CSV)
GSE139657_aav_antibody_all.csv.gz 2.0 Mb (ftp)(http) CSV
GSE139657_aav_maap_all.csv.gz 10.2 Mb (ftp)(http) CSV
GSE139657_aav_mouse_all.csv.gz 13.2 Mb (ftp)(http) CSV
GSE139657_aav_packaging_all.csv.gz 19.2 Mb (ftp)(http) CSV
GSE139657_aav_thermostability_all.csv.gz 5.7 Mb (ftp)(http) CSV
GSE139657_sample_sheet_Liver.csv.gz 433 b (ftp)(http) CSV
GSE139657_sample_sheet_plasmid.csv.gz 329 b (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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