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Series GSE139583 Query DataSets for GSE139583
Status Public on Oct 23, 2020
Title RNA sequencing results of dipyridamole treatment in SLC29A2-expressing SK-hep1 cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We observed an increasing trend of nuclear SLC29A2 expression associated with high histological de-differentiation grades, metastasis and poor patient prognosis by immunohistochemical analysis of HCC tumors. Treatments of dipyridamole to SLC29A2 expressing SK-hep1 cells reduced cell viability and cell migration. To examine the anticancer activities of dipyridamole, transcriptome analysis was performed to detect the modulations of oncogenic SLC29A2 and the downstream signaling pathways.
Overall design Gene expression profiles of dipyridamole and/or sorafenib treatment in SLC29A2-expressing Sk-hep1 cells were generated by Illumina RNA sequencing and compared to profiles derived from mock control cells.
Contributor(s) Shen R, Jou Y
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Submission date Oct 30, 2019
Last update date Oct 25, 2020
Contact name Roger Shen
Organization name Academia Sinica
Street address 128 Sec. 2, Academia Rd. Nankang
City Taipei
ZIP/Postal code 11529
Country Taiwan
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (8)
GSM4143977 V_DM
GSM4143978 V_S
GSM4143979 V_D
BioProject PRJNA580370
SRA SRP227430

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139583_RAW.tar 2.5 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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