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Series GSE139492 Query DataSets for GSE139492
Status Public on Oct 29, 2019
Title CD47 blockade augmentation of Trastuzumab antitumor efficacy dependent upon antibody-dependent-cellular-phagocytosis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Analysis of HER2 breast tumor immune infiltrates in mice treated with murine Trastuzumab and CD47 checkpoint blockade therapy
 
Overall design Single Cell RNA Seq (scRNAseq) was performed on endogenous HER2-driven breast cancer in transgenic mice. The goal of this experiment is to compare effects of different antibody therapy combinations on tumor macrophages transcriptome
 
Contributor(s) Tsao L, Agarwal P, Crosby EJ, Lyerly HK, Hartman ZC
Citation(s) 31689243
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 CA238217 Enabling effective anti-tumor immunity from targeted antibodies through dual innate and adaptive immune checkpoint blockade in non-immunogenic cancers DUKE UNIVERSITY Zachary Conrad Hartman
Submission date Oct 28, 2019
Last update date Apr 10, 2020
Contact name Zachary Conrad Hartman
E-mail(s) zch@duke.edu
Phone 919-684-9197
Organization name Duke University
Department Surgery
Lab Lyerly Lab
Street address Research Drive MSRB rm 414
City Durham
State/province NC
ZIP/Postal code 27710
Country USA
 
Platforms (2)
GPL21273 HiSeq X Ten (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (13)
GSM4142329 Isotype antibody [UN_241A]
GSM4142330 Untreated [UN_698A]
GSM4142331 Untreated [UN_698B]
This SubSeries is part of SuperSeries:
GSE148482 Stimulation of oncogene-specific tumor infiltrating T-cells through combined vaccine and alpha-PD1 enable sustained anti-tumor responses against established HER2 breast cancer (BC)
Relations
BioProject PRJNA579973
SRA SRP227233

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Supplementary file Size Download File type/resource
GSE139492_RAW.tar 997.8 Mb (http)(custom) TAR (of TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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