GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE139485 Query DataSets for GSE139485
Status Public on Oct 29, 2019
Title RNA-sequence facilitates analyze changes of signaling pathways after drug treatment
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mammalian cochlear hair cells cannot regenerate after damage, which was a cause of hearing loss. Due to the small number of cochlear hair cells, we were unable to collect enough cells for research. Therefore, we have established a inner ear organoid model in this way, which greatly expands the number of supporting cells, Lgr5 and gradually mature hair cells. It can be used in high-throughput screening experiments. Using this model for high-throughput screening of FDA small molecule Drug, we found that Regorafenib can promote hair cell regeneration in vitro and get more mature regenerated hair cells. And we found that Regorfenib was though a new VEGF-TGFB axis to regulate hair cell regeneration.
Overall design Compare these changes in these signal pathways after drug treatment
Contributor(s) Zhang L
Citation(s) 34525385
Submission date Oct 28, 2019
Last update date Oct 06, 2021
Contact name Qing Liu
Phone 13585190481
Organization name Model Animal Research Center, Nanjing University
Street address No. 12 Xuefu Road, Pukou District
City Nanjing
ZIP/Postal code 211800
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (9)
GSM4142176 d1CHIR_1
GSM4142177 d1CHIR_2
GSM4142178 d1CHIR_3
BioProject PRJNA579963
SRA SRP227216

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139485_D1CHIR_VS_D1_1178.txt.gz 7.6 Kb (ftp)(http) TXT
GSE139485_D1_CHIR_VS_D1_DAPT.txt.gz 3.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap