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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 29, 2019 |
| Title |
Whole transcriptome sequencing of Treg with and without Mef2d, Mef2c, HDAC1, HDAC2 or Dyrk1 deletion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Mef2d, Mef2c, HDAC1, HDAC2 and Dyrk1 are involved with Foxp3 Treg regulation. Conditional deletion of either gene in Foxp3 Treg (cre/loxP) was generated and RNA sequenced and analyzed via Novogene, Inc.
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| Overall design |
Foxp3+ regulatory T cells from mice with or without a Foxp3-conditional Mef2d, Mef2c, HDAC1, HDAC2 or Dyrk1 deletion (Mef2d-fl/flFoxp3cre, Mef2c-fl/flFoxp3cre, HDAC1-fl/flFoxp3cre, HDAC2-fl/flFoxp3cre or Dyrk1-fl/flFoxp3YFPcre and Foxp3YFPcre mice) had RNA isolated. The RNA samples, with three independent biological replicates per group, were sent to NovoGene for mRNA sequencing using the Illuminia PE150 platform.
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| Contributor(s) |
Di Giorgio E, Wang L, Xiong Y, Han R, Beier UH, Hancock WW |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 28, 2019 |
| Last update date |
Oct 29, 2019 |
| Contact name |
Wayne W Hancock |
| Organization name |
CHOP/UPenn
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| Street address |
916B ARC, 3615 Civic Ctr Blvd
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104-4318 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA579929 |
| SRA |
SRP227204 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE139480_processed_data.txt.gz |
2.0 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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