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Series GSE139480 Query DataSets for GSE139480
Status Public on Oct 29, 2019
Title Whole transcriptome sequencing of Treg with and without Mef2d, Mef2c, HDAC1, HDAC2 or Dyrk1 deletion
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mef2d, Mef2c, HDAC1, HDAC2 and Dyrk1 are involved with Foxp3 Treg regulation. Conditional deletion of either gene in Foxp3 Treg (cre/loxP) was generated and RNA sequenced and analyzed via Novogene, Inc.
Overall design Foxp3+ regulatory T cells from mice with or without a Foxp3-conditional Mef2d, Mef2c, HDAC1, HDAC2 or Dyrk1 deletion (Mef2d-fl/flFoxp3cre, Mef2c-fl/flFoxp3cre, HDAC1-fl/flFoxp3cre, HDAC2-fl/flFoxp3cre or Dyrk1-fl/flFoxp3YFPcre and Foxp3YFPcre mice) had RNA isolated. The RNA samples, with three independent biological replicates per group, were sent to NovoGene for mRNA sequencing using the Illuminia PE150 platform.
Contributor(s) Di Giorgio E, Wang L, Xiong Y, Han R, Beier UH, Hancock WW
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Submission date Oct 28, 2019
Last update date Oct 29, 2019
Contact name Wayne W Hancock
Organization name CHOP/UPenn
Street address 916B ARC, 3615 Civic Ctr Blvd
City Philadelphia
State/province PA
ZIP/Postal code 19104-4318
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (18)
GSM4142105 wild type Treg replicate 1
GSM4142106 wild type Treg replicate 2
GSM4142107 wild type Treg replicate 3
BioProject PRJNA579929
SRA SRP227204

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Supplementary file Size Download File type/resource
GSE139480_processed_data.txt.gz 2.0 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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