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| Status |
Public on Dec 20, 2019 |
| Title |
Nickel induced transcriptional changes persist post exposure through epigenetic reprograming (ChIP-seq & RNA-seq datasets) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Nickel is an occupational and environmental toxicant associated with a number of diseases. Our earlier studies showed that Ni-induced alterations to global gene expression persist even after the termination of exposure. A number of earlier studies suggest epigenome as a target of Ni. However, the genome wide dynamics of epigenetic modifications that potentially drive Ni-induced long-term transcriptional changes remain elusive.
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| Overall design |
In this study, we performed a comprehensive analysis of the transcriptome and the epigenome of human epithelial cells during and after termination nickel exposure.
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| Contributor(s) |
Zang C, Cuddapah S |
| Citation(s) |
31856895 |
| |
| Submission date |
Oct 24, 2019 |
| Last update date |
Jan 08, 2020 |
| Contact name |
Zhenjia Wang |
| Organization name |
University of Virginia
|
| Department |
Center for Public Health Genomics
|
| Street address |
1300 Jefferson Park Avenue
|
| City |
Charlottesville |
| State/province |
VIRGINIA |
| ZIP/Postal code |
22908 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE139356 |
Nickel induced transcriptional changes persist post exposure through epigenetic reprograming |
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| Relations |
| BioProject |
PRJNA579383 |
| SRA |
SRP226882 |
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