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Series GSE138778 Query DataSets for GSE138778
Status Public on Dec 04, 2020
Title Profiling Kupffer cells with different origins in NASH
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Kupffer cells (KCs) self-renew by local proliferation in the adult independently from monocytes (Mos). However, how they maintain during chronic metabolic disorders such as non-alcoholic steatohepatitis (NASH) remains ill-defined. We characterized KCs during NASH and observed diversity in the KC pool, with a significant fraction of monocyte-derived KCs (MoKCs). Here, we aim to uncover the transcriptional landscapes of KCs subsets found in a mouse model of methionine and choline deficient (MCD)-diet induced non-alcoholic steatohepatitis (NASH).
Overall design Wild-type mice were fed a MCD diet for 4 weeks and Kupffer cell subsets were sorted by flow cytometry. EmKCs were CLEC2+ TIMD4+ while MoKCs were CLEC2+ TIMD4-.
Contributor(s) Dussaud S, Gautier E
Citation(s) 32562600
Submission date Oct 11, 2019
Last update date Dec 04, 2020
Contact name Sebastien Dussaud
Organization name UPMC
Street address 91 bd de l'hopital
City Paris
ZIP/Postal code 75013
Country France
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (19)
GSM4119149 Chow_EmKCs 1
GSM4119150 Chow_EmKCs 2
GSM4119151 Chow_EmKCs 3
BioProject PRJNA577115
SRA SRP225214

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Supplementary file Size Download File type/resource
GSE138778_Counts.csv.gz 2.3 Mb (ftp)(http) CSV
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