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Series GSE138709 Query DataSets for GSE138709
Status Public on Jun 06, 2020
Title Dissecting the transcriptomic landscape of the human intrahepatic cholangiocarcinoma by single cell RNA-sequencing
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising in the liver, featured with high tumor heterogeneity and dismal prognosis. The cellular disversity and molecular basis of tumor cells interacted with surrounding niche cells remains poorly understood, limiting the development of targeted anti-tumor therapies.
Overall design To comprehensively elucidate the ICC heterogeneity, we employed single-cell RNA sequencing (scRNA-seq) to profile 31,302 cells of five ICC samples, as well as three paired adjacent non-tumor tissues. Our results identify 31 cell subtypes and the heterogeneous malignant subtype was highly patient-specific, which has differential proliferative, migratory and inflammation phenotype.
Contributor(s) Zhang M, Yang H, Liu B, Yan X
Citation Zhang M, Yang H, Wan L, Wang Z, Wang H, Ge C, Liu Y, Hao Y, Zhang D, Shi G, Gong Y, Ni Y, Wang C, Zhang Y, Xi J, Wang S, Shi L, Zhang L, Yue W, Pei X, Liu B, and Yan X. Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. Journal of Hepatology (2020). doi:10.1016/j.jhep.2020.05.039
Submission date Oct 10, 2019
Last update date Aug 02, 2022
Contact name Min Zhang
Phone 13241302826
Organization name Academy of Military Medical Sciences
Department The Fifth Medical Center of Chinese PLA General Hospital
Street address No. 8 East Road, Fengtai District
City Beijing
State/province Beijing
ZIP/Postal code 100071
Country China
Platforms (2)
GPL20795 HiSeq X Ten (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (8)
GSM4116579 ICC_18_Adjacent: BAJD-20180619-12-171239-18N
GSM4116580 ICC_18_Tumor: BAJD-20180619-12-171239-18T
GSM4116581 ICC_20_Tumor: 171239A-ccc20T
BioProject PRJNA576876
SRA SRP225078

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Supplementary file Size Download File type/resource
GSE138709_RAW.tar 76.6 Mb (http)(custom) TAR (of CSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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