GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE138437 Query DataSets for GSE138437
Status Public on Mar 01, 2020
Title Sequencing of commercially-available pancreatic cancer cell lines reveals selective CYP3A5 overexpression among xenobiotic-metabolizing CYPs.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: To know the expression of all cytochrome P450 (CYP) enzymes and related drug metabolizing enzymes in pancreatic cancer models
Methods: We obtained expression profiles of 8 commercially-available pancreatic cancer cell lines and one non-cancerous immortalized cell line by RNA-sequencing. The pancreatic cancer cells were compared among themselves and to the non-cancerous control cells.
Results: We confirmed reports that CYP3A5 is highly overexpressed in pancreatic cancer models, and additionally report that known xenobiotic-metabolizing CYPs are lowly expressed in comparison.
Overall design mRNA profiles of each cell line were obtaiend in triplicate using Illumina-based RNA-Sequencing. Sequencing was conducted as paired-end 100bp reads. The HPNE (non-cancerous pancreatic cells) group is considered as the control.
Contributor(s) Wright WC, Oladimeji PO, Chen T
Citation(s) 31965799
Submission date Oct 04, 2019
Last update date Nov 22, 2021
Contact name William C. Wright
Organization name St. Jude Children's Research Hospital
Department Computational Biology
Street address 262 Danny Thomas Pl
City Memphis
State/province Tennessee
ZIP/Postal code 38105
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (27)
GSM4107960 ASPC1_1
GSM4107961 ASPC1_2
GSM4107962 ASPC1_3
BioProject PRJNA575858

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138437_Log2CPM1.csv.gz 2.8 Mb (ftp)(http) CSV
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap