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Series GSE138403 Query DataSets for GSE138403
Status Public on Oct 04, 2019
Title Propranolol exhibits activity against hemangiomas independent of beta blockade
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Propranolol is a widely used beta blocker that consists of a racemic mixture of R and S stereoisomers. Only the S stereoisomer has significant activity against the beta-adrenergic receptor. A fortuitous clinical observation was made in an infant who received propranolol for cardiac disease, and regression of a hemangioma of infancy was noted. order to gain further insights in the mechanisms of action of R-propranolol in vivo, we subjected vehicle- and R-propranolol-treated tumors to RNAseq analysis. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that choline metabolism was the pathway most affected by R-propranolol treatment. Consistent with this, the most highly regulated gene by R-propranolol treatment was Betaine-Homocysteine Methyl Transferase (Bhmt). Other genes that are involved in tumor suppressive activities such as Early Growth Response 1 (Egr1) and AP-1 subunit, which are both transcription factors implicated in tumor suppression. Egr1 regulates important tumor suppressors such as PTEN and p53, and upregulates tumor necrosis factor α (TNF-α). Fos, which has been known to be rearranged and expressed frequently in epithelioid hemangioma, was also upregulated in R-propranolol-treated samples. The genes identified in the RNAseq analysis pose as interesting targets for further investigations.
Overall design Analysis of transcriptome regulation in R-propranolol treated tumors
Contributor(s) Sasaki M, North P, Elsey J, Bubley J, Rao S, Jung Y, Wu S, Zou M, Pollack BP, Kumar J, Singh H, Arbiser JL
Citation(s) 31701018
Submission date Oct 03, 2019
Last update date Jan 03, 2020
Contact name Jack L Arbiser
Phone 404-727-5063
Organization name Emory School of Medicine
Department Dermatology
Lab Arbiser
Street address 101 Woodruff Circle WMB 5309
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (9)
GSM4106773 J906_1_Cont_1
GSM4106774 J906_1_Cont_2
GSM4106775 J906_3_Cont_3
BioProject PRJNA575740

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138403_Gene_Counts_unfiltered.txt.gz 348.9 Kb (ftp)(http) TXT
Raw data are available in SRA
Processed data are available on Series record

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