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Series GSE138372 Query DataSets for GSE138372
Status Public on Apr 15, 2020
Title Regeneration of pulpo-dentinal-like complex by a group of unique multipotent CD24a positive stem cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In this study, through three-dimensional spheroid culture, a group of unique multipotent stem cells were identified from mouse dental papilla, called multipotent dental pulp-regenerative stem cells (MDPSCs). MDPSCs exhibited enhanced osteo/odontogenic differentiation capabilities and could form regenerative dentin and neurovascular-like structures that mimicked the native teeth in vivo. Further analysis revealed that CD24a was the bona fide marker for MDPSCs and their expansion was highly dependent on the expression of a key transcriptional factor Sp7. Finally, CD24a positive cells could be detected in primary dental papilla in mice and human, suggesting MDPSCs resided in their native niches. Together, our study has identified a novel group of multipotent pulpregenerative stem cells with defined molecular markers for the potential treatment of pulpitis and pulp necrosis.
Overall design Three group of cells (every group in triplicate) including monolayer cells, DPC Spheres and DPC P2 mRNA profiles were sequenced.
Contributor(s) Chen H, Fu H, Wu X, Duan Y, Zhang S, Hu H, Liao Y, Wang T, Yang Y, Chen G, Li Z, Tian W
Citation(s) 32284993
Submission date Oct 03, 2019
Last update date Apr 15, 2020
Contact name Zhonghan Li
Organization name Sichuan University
Department College of Life Sciences
Street address 29 Wangjiang Road
City Chengdu
State/province Sichuan
ZIP/Postal code 610064
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (9)
GSM4106177 DPC primary cells-1
GSM4106178 DPC primary cells-2
GSM4106179 DPC primary cells-3
BioProject PRJNA575657

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138372_raw_counts.tsv.gz 1.4 Mb (ftp)(http) TSV
Raw data are available in SRA
Processed data are available on Series record

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