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Series GSE138312 Query DataSets for GSE138312
Status Public on Jun 30, 2021
Title Transcriptomic analysis of induced pluripotent stem cells (iPSC) and differentiated hepatocytes (iPSC-Heps) from a cohort of healthy subjects and patients with nonalcoholic fatty liver disease (NAFLD)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We report that the transcriptomic profiles of iPSC-Heps from NAFLD patients are distinct from those of healthy controls. This is in contrast to the transcriptomic profiles of the parent iPSC, which are similar between NAFLD patients and healthy controls.
Overall design iPSC were generated from peripheral blood mononuclear cells from 16 healthy control subjects and 21 patients with biopsy-proven NAFLD. iPSC from all 37 subjects were differentiated to hepatocytes (iPSC-Heps). RNA from iPSC and iPSC-Heps were analyzed independently using the Illumina HiSeq 3000 Sequencing System.
Contributor(s) Duwaerts CC, Her CL, Hoffman ES, Siao K, Phillips NJ, Willenbring H, Mattis AN, Maher JJ
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NIH grant(s)
Grant ID Grant title Affiliation Name
R21 DK118380 Using disease-specific iPS cells to investigate fatty liver disease in a diverse human cohort University of California San Francisco JACQUELYN J. MAHER
Submission date Oct 02, 2019
Last update date Jun 30, 2021
Contact name Jacquelyn J Maher
Organization name University of California San Francisco
Department Medicine
Lab Box 0538, HSE 1424
Street address 513 Parnassus Avenue
City San Francisco
State/province CA
ZIP/Postal code 94143
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (74)
GSM4105200 C1iPSC Batch 1
GSM4105201 C2iPSC Batch 1
GSM4105202 C3iPSC Batch 1
BioProject PRJNA575498

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Supplementary file Size Download File type/resource
GSE138312_iHep_rsem_BATCH1.xlsx 4.5 Mb (ftp)(http) XLSX
GSE138312_iPSC_GSE138312_iHep_rsem_BATCH2.xlsx 3.1 Mb (ftp)(http) XLSX
GSE138312_iPSC_rsem_BATCH1.xlsx 4.6 Mb (ftp)(http) XLSX
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