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| Status |
Public on Jun 30, 2021 |
| Title |
Transcriptomic analysis of induced pluripotent stem cells (iPSC) and differentiated hepatocytes (iPSC-Heps) from a cohort of healthy subjects and patients with nonalcoholic fatty liver disease (NAFLD) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that the transcriptomic profiles of iPSC-Heps from NAFLD patients are distinct from those of healthy controls. This is in contrast to the transcriptomic profiles of the parent iPSC, which are similar between NAFLD patients and healthy controls.
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| Overall design |
iPSC were generated from peripheral blood mononuclear cells from 16 healthy control subjects and 21 patients with biopsy-proven NAFLD. iPSC from all 37 subjects were differentiated to hepatocytes (iPSC-Heps). RNA from iPSC and iPSC-Heps were analyzed independently using the Illumina HiSeq 3000 Sequencing System.
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| Contributor(s) |
Duwaerts CC, Her CL, Hoffman ES, Siao K, Phillips NJ, Willenbring H, Mattis AN, Maher JJ |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R21 DK118380 |
Using disease-specific iPS cells to investigate fatty liver disease in a diverse human cohort |
University of California San Francisco |
JACQUELYN J. MAHER |
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| Submission date |
Oct 02, 2019 |
| Last update date |
Jun 30, 2021 |
| Contact name |
Jacquelyn J Maher |
| Organization name |
University of California San Francisco
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| Department |
Medicine
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| Lab |
Box 0538, HSE 1424
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| Street address |
513 Parnassus Avenue
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| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (74)
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| Relations |
| BioProject |
PRJNA575498 |
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