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Series GSE138272 Query DataSets for GSE138272
Status Public on Dec 15, 2019
Title FOXP3 protects conventional human T cells from premature restimulation-induced cell death
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48, which in turn sustains basal autophagy and suppresses pro-apoptotic p53 signaling. Our findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.
Overall design Purified human CD4 T cells were electroporated with siRNAs against FOXP3 or negative-control medum GC duplex siRNA and differential gene expression analysis was performed using mRNA sequencing.
Contributor(s) Dalgard CL, Snow AL
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Submission date Oct 01, 2019
Last update date Dec 15, 2019
Contact name Clifton Lee Dalgard
Organization name Uniformed Services University
Department Anatomy Physiology & Genetics
Lab Dalgard
Street address 4301 Jones Bridge Road B2038
City Bethesda
State/province Maryland
ZIP/Postal code 20814
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (20)
GSM4104216 CD4_siNS_rep1
GSM4104217 CD4_siNS_rep2
GSM4104218 CD4_siNS_rep3
BioProject PRJNA575256
SRA SRP223894

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Supplementary file Size Download File type/resource
GSE138272_FOXP3_sample_gene_FPKMs.txt.gz 828.3 Kb (ftp)(http) TXT
GSE138272_FOXP3_sample_gene_expected_counts.txt.gz 933.4 Kb (ftp)(http) TXT
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Processed data are available on Series record

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