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Series GSE138153 Query DataSets for GSE138153
Status Public on Oct 01, 2020
Title Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Epigenetic regulation of gene expression through histone modifications like methylation of various lysine residues are essential for embryonic development. Here we removed SETD2, a methyltransferase for histone 3 lysine 36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and show it is required for proper area patterning (arealization) of the neocortex and the formation of thalamo-cortico-thalamic circuits by maintaining the expression of clustered protocadherin (Pcdh) genes in an H3K36me3 methyltransferase-dependent manner. Moreover, the Setd2 mutant mice exhibit defects in social interaction, motor endurance and spatial memory, reminiscent of patients with the Sotos-like syndrome bearing SETD2 mutations.
Overall design Cortex mRNA profiles of E13.5 control and Emx1-Cre;Setd2 fl/fl mice were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000.
Contributor(s) Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu F, Wu X, Wu M, Zhou Y
Citation(s) 33523829
Submission date Sep 30, 2019
Last update date Feb 08, 2021
Contact name Lichao Xu
Organization name Wuhan University
Street address luojiashan
City Wuhan
ZIP/Postal code 430000
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM4101022 Cortex, control rep1
GSM4101023 Cortex, control rep2
GSM4101024 Cortex, control rep3
BioProject PRJNA574933
SRA SRP223695

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138153_GO_rich_down-regulated_genes.txt.gz 4.3 Kb (ftp)(http) TXT
GSE138153_samples_fpkm.txt.gz 2.5 Mb (ftp)(http) TXT
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Processed data are available on Series record

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