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Series GSE138123 Query DataSets for GSE138123
Status Public on Sep 17, 2020
Title METTL5, an 18S rRNA-specific m6A methyltransferase, regulates the Integrated Stress Response [eCLIP]
Organism Homo sapiens
Experiment type Other
Summary RNA N6-methyladenosine (m6A) modification is present in different RNA molecules, including protein-coding mRNAs and non-coding RNAs such as ribosomal RNAs (rRNAs).Here, we report that mammalian METTL5, a member of a highly conserved methyltransferase family, specifically methylates adenosine 1832 (A1832) in the 18S rRNA in vivo and in vitro.
Overall design We used eCLIP-seq to identify the binding targets of METTL5 in human 293T cells.
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Contributor(s) Chen H, Shi Y
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Submission date Sep 27, 2019
Last update date Sep 17, 2020
Contact name Yang Shi
Street address 320 LONGWOOD AVE
City Boston
State/province Massachusetts
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (3)
GSM4100711 Input
GSM4100712 eCLIP_1
GSM4100713 eCLIP_2
BioProject PRJNA574656
SRA SRP223540

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Supplementary file Size Download File type/resource
GSE138123_rRNA-counts.xlsx 405.3 Kb (ftp)(http) XLSX
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Processed data are available on Series record

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