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Series GSE137931 Query DataSets for GSE137931
Status Public on Dec 15, 2019
Title CD48-dependent protective autophagy in conventional human T cells promotes restimulation-induced cell death resistance
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48, which in turn sustains basal autophagy and suppresses pro-apoptotic p53 signaling. Our findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.
Overall design Purified human CD4 T cells were electroporated with siRNAs against CD48 or negative-control medum GC duplex siRNA and differential gene expression analysis was performed using mRNA sequencing.
Contributor(s) Dalgard CL, Snow AL
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Submission date Sep 24, 2019
Last update date Dec 15, 2019
Contact name Clifton Lee Dalgard
Organization name Uniformed Services University
Department Anatomy Physiology & Genetics
Lab Dalgard
Street address 4301 Jones Bridge Road B2038
City Bethesda
State/province Maryland
ZIP/Postal code 20814
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (10)
GSM4094596 CD4_siNS_isotype_rep1
GSM4094597 CD4_siNS_isotype_rep2
GSM4094598 CD4_siNS_isotype_rep3
BioProject PRJNA573899
SRA SRP223086

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137931_CD48_sample_gene_FPKMs.txt.gz 904.3 Kb (ftp)(http) TXT
GSE137931_CD48_sample_gene_counts.txt.gz 606.0 Kb (ftp)(http) TXT
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Processed data are available on Series record

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