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Series GSE137785 Query DataSets for GSE137785
Status Public on Sep 17, 2022
Title Sel1L-Hrd1 ERAD is required for the maintainenance of beta cell identity and function
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mice with Sel1L deficient beta cells develop severe hyperglycemia, glucose intolerance and impaired insulin secretion. Using single cell sequencing, we identified that Sel1L plays a major role in maintaining beta cell maturation by suppressing TGF-beta signaling.
Overall design Islets were isolated from 5 weeks old Sel1Lf/f and Sel1LIns1 mice and following overnight recovery, trypsinized to obtain single cell suspension and processed using 10X Genomics CHROMIUM single cell 3' solution.
Contributor(s) Shrestha N, Qi L
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Submission date Sep 20, 2019
Last update date Sep 19, 2022
Contact name Neha Shrestha
Organization name University of Michigan
Street address 1000 Wall Street
City Ann Arbor
State/province MI
ZIP/Postal code 48195
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM4087829 WT-1
GSM4087830 WT-2
GSM4087831 KO-1
BioProject PRJNA573076
SRA SRP222820

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Supplementary file Size Download File type/resource
GSE137785_RAW.tar 66.0 Mb (http)(custom) TAR (of CSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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