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Series GSE137619 Query DataSets for GSE137619
Status Public on Mar 23, 2020
Title The choroid plexus in progressive multiple sclerosis presents hypoxia and secretory changes that may be related to neuroprotection
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The choroid plexus (CP) is a key regulator of central nervous system (CNS) homeostasis through its secretory, immunological and barrier properties. Accumulating evidence suggests that the CP plays a pivotal role in the pathogenesis of multiple sclerosis (MS), but the underlying mechanisms remain largely elusive. To get a comprehensive view on the role of the CP in MS pathogenesis, we studied transcriptomic alterations of the human CP in progressive MS compared to controls using an RNA sequencing approach. We identified 17 genes with significantly higher expression in progressive MS patients relative to that in controls. Among them is the newly described long non-coding RNA HIF1A-AS3. Next to that, we uncovered disease-affected pathways related to hypoxia, secretion and neuroprotection, while only subtle immunological and no barrier alterations were observed. Three of the differentially expressed genes encode for secreted proteins, namely ADM, PAI-1 (SERPINE1) and STC2. Together, these findings provide novel insights to target the CP during MS and promote the secretion of neuroprotective factors into the CNS of progressive MS patients.
Overall design Post-mortem samples from Whole Choroid Plexus of Primary Progressive Multiple Sclerosis patients and non-neurological controls were sequenced using Illumina Hiseq 3000 and differential expression was assesed using DESeq2
Contributor(s) Rodríguez-Lorenzo S, Ferreira-Francisco DM
Citation(s) 32192527
Submission date Sep 17, 2019
Last update date Mar 30, 2020
Contact name Helga E de Vries
Organization name Amsterdam UMC
Department MCBI
Street address De Boelelaan 1108
City Amsterdam
ZIP/Postal code 1007 MB
Country Netherlands
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (12)
GSM4083354 Control CP 1
GSM4083355 Control CP 2
GSM4083356 Control CP 3
BioProject PRJNA566011
SRA SRP222107

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Supplementary file Size Download File type/resource
GSE137619_RAW.tar 2.6 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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