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Series GSE137453 Query DataSets for GSE137453
Status Public on Jul 29, 2020
Title Long noncoding RNA expression profiles analysis in GBM patient-derived cells stimulated with interferon gamma
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Long noncoding RNAs (lncRNAs) are key regulators of gene expression both in physiological and pathological conditions. Previous studies showed changes in lncRNA expression during tumorigenesis. To analyze the role of lncRNAs in tumor interferon signaling and cancer-mediated immunosuppression, we used RNA-seq technique to identify lncRNAs that are differentially expressed in GBM patient-derived cells stimulated with interferon gamma compared to unstimulated cells. 15,768 lncRNAs were surveyed in the analysis. RNA-seq data show upregulation of 113 lncRNAs upon interferon gamma treatment (p value < 0.01, fold change > 2). Our findings indicate that the expression of several lncRNAs is stimulated by interferon gamma suggesting a critical role of lncRNAs in tumor interferon signaling.
Overall design Patient-derived GBM cells were stimulated with interferon gamma for 24 hours. Non stimulated cells were used as control. LncRNA expression profiles were generated by RNA-seq, in triplicate, using Illumina HiSeq 4000.
Contributor(s) Mineo M, Chiocca EA
Citation(s) 32504554
Submission date Sep 15, 2019
Last update date Jul 29, 2020
Contact name Marco Mineo
Phone 6175255656
Organization name Brigham and Women's Hospital
Street address 60 Fenwood Rd, BTM 8012
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (6)
GSM4079638 Control_1
GSM4079639 Control_2
GSM4079640 Control_3
This SubSeries is part of SuperSeries:
GSE137489 Long noncoding RNA INCA1 regulates tumor interferon signaling.
BioProject PRJNA565586
SRA SRP221666

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Supplementary file Size Download File type/resource
GSE137453_BT333.txt.gz 115.6 Kb (ftp)(http) TXT
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