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Series GSE137386 Query DataSets for GSE137386
Status Public on Sep 01, 2020
Title Transcriptional control of influenza-specific CD4+ tissue-resident memory T cell generation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Tissue-resident memory T cells (TRM) are a non-circulating subset of memory that are maintained at sites of pathogen entry and mediate optimal protection against reinfection. Lung TRM can be generated in response to respiratory infection or vaccination, however, the molecular pathways involved in CD4+TRM establishment have not been defined. Here, we performed transcriptional profiling of influenza-specific lung CD4+TRM following influenza infection to identify pathways implicated in CD4+TRM generation and homeostasis. Lung CD4+TRM displayed a unique transcriptional profile distinct from spleen memory, including up-regulation of a gene network induced by the transcription factor IRF4, a known regulator of effector T cell differentiation.
Overall design Transcriptional profiling by RNA-Seq of lung-resident and spleen influenza-specific mouse CD4+ T cells. Project includes four and five biological replicates of each sample type, respectively.
Contributor(s) Cvetkovski F, Snyder ME, Farber DL
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Submission date Sep 13, 2019
Last update date Sep 01, 2020
Contact name Donna L Farber
Organization name Columbia University
Department Surgery
Street address 650 West 168th Street, BB1701
City New York
State/province NY
ZIP/Postal code 10032
Country USA
Platforms (2)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (9)
GSM4078081 LungRep1
GSM4078082 LungRep2
GSM4078083 SpleenRep1
BioProject PRJNA565358
SRA SRP221552

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137386_counts.csv.gz 1.3 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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