GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE137266 Query DataSets for GSE137266
Status Public on Sep 12, 2019
Title Single-nucleus chromatin accessibility maps of IDH mutant gliomas point to non-coding RNAs as a major influence on heterogeneity
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We generated chromatin accessibility maps from 5 tumors, 336 individual nuclei, using the Fluidigm HT IFC microfluidics platform (snATAC-Seq). We were able to identify variable promoter accessibility of non-coding RNAs in LGGs.
Our results point to increased CYTOR promoter accessibility in IDH-intact samples. We obtained two distinct clusters, primarily driven by histology, with a more constrained IDH-codel/oligodendroglioma cluster.
Overall design Examination of open chromatin accessibility in 336 nuclei from 5 low grade tumors

>>>Submitter states that raw data are unavailable due to patient privacy concerns<<<
Contributor(s) Al-Ali R, Turcan S
Citation(s) 31806013
Submission date Sep 11, 2019
Last update date Dec 12, 2019
Contact name Ruslan Al-Ali
Organization name University Hospital Heidelberg
Lab Sevin Turcan
Street address INF 400
City Heidelberg
State/province Baden Wurttemberg
ZIP/Postal code 69120
Country Germany
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (5)
GSM4074157 Astro1
GSM4074158 Astro2
GSM4074159 Astro3
BioProject PRJNA564978

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137266_RAW.tar 4.9 Mb (http)(custom) TAR (of TAR)
Processed data provided as supplementary file
Raw data not provided for this record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap