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Series GSE137207 Query DataSets for GSE137207
Status Public on Sep 09, 2020
Title Pattern occupation of HDACs on chromatin determines PI3K/AKT inhibitor resistance in cancers [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Blocking BRD4 or HDACs induces paradoxically similar gene expression, comparably attenuates PI3K/AKT inhibitor resistance in multiple cancer cells.
Overall design To determine the distribution changes of H3K27-ac and BRD4 in PC-3-GDC-R cells (w/o iCBP112 and SAHA treatments), we performed ChIP-seq for H3K27ac and BRD4 in PC-3-control+vehicle, PC-3-GDC-R+vehicle, PC-3-GDC-R+iCBP112 and PC-3-GDC-R+SAHA cells.
Contributor(s) Huang H, Wu D, Ye Z
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Submission date Sep 10, 2019
Last update date Sep 13, 2020
Contact name Zhenqing Ye
Organization name UT Health San Antonio
Department 6Department of Population Health Sciences
Street address 8403 Floyd Curl Dr
City San Antonio
State/province TX
ZIP/Postal code 78229
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (18)
GSM4072996 control_vehicle_H3K27ac_rep1
GSM4072997 control_vehicle_H3K27ac_rep2
GSM4072998 GDC-R_vehicle_H3K27ac_rep1
This SubSeries is part of SuperSeries:
GSE137209 Bromodomain and HDAC inhibitors equivalently suppress PI3K/AKT inhibition resistance in cancers
BioProject PRJNA564807
SRA SRP221263

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137207_RAW.tar 1.7 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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