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| Status |
Public on Sep 09, 2020 |
| Title |
Pattern occupation of HDACs on chromatin determines PI3K/AKT inhibitor resistance in cancers [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Blocking BRD4 or HDACs induces paradoxically similar gene expression, comparably attenuates PI3K/AKT inhibitor resistance in multiple cancer cells.
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| Overall design |
To determine the distribution changes of H3K27-ac and BRD4 in PC-3-GDC-R cells (w/o iCBP112 and SAHA treatments), we performed ChIP-seq for H3K27ac and BRD4 in PC-3-control+vehicle, PC-3-GDC-R+vehicle, PC-3-GDC-R+iCBP112 and PC-3-GDC-R+SAHA cells.
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| Contributor(s) |
Huang H, Wu D, Ye Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 10, 2019 |
| Last update date |
Sep 13, 2020 |
| Contact name |
Zhenqing Ye |
| E-mail(s) |
iamyezhenqing@gmail.com
|
| Organization name |
UT Health San Antonio
|
| Department |
6Department of Population Health Sciences
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| Street address |
8403 Floyd Curl Dr
|
| City |
San Antonio |
| State/province |
TX |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE137209 |
Bromodomain and HDAC inhibitors equivalently suppress PI3K/AKT inhibition resistance in cancers |
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| Relations |
| BioProject |
PRJNA564807 |
| SRA |
SRP221263 |
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