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Series GSE137167 Query DataSets for GSE137167
Status Public on Dec 30, 2019
Title Single cell RNA-sequencing of cardiac CD45+ populations in mouse with transverse aortic constriction (TAC)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary It is already well known that the immune cells called macrophages are involved in the mechanisms of heart failure (HF). Macrophages are divised into several subtypes based on behavior.Some subsets are highly inflammatory, while some support tissue repair. Recent studies have suggested that the classical M1/M2 classification is not suitable for some pathological processes of the heart. Single cell sequencing (scSeq) is an ideal tool to clarify the macrophage heterogeneity in HF. It provided a higher resolution of cellular differences and a better understanding of individual cell function. In this study, we aimed to identify a macrophage subset that linked with heart failure, and furtherly screen the target and investigate the mechanism.
Overall design CD45+ cells from heart of mice with/without TAC (6 per group) were sorted and the mRNA profiles of single cells were investagted by 10x Genomics technology
Contributor(s) Lu L, Shi-Hao N
Citation(s) 34100920
Submission date Sep 09, 2019
Last update date Nov 14, 2021
Contact name Lu Lu
Organization name Guangzhou University of Chinese Medicine
Street address No.12,Airport Road,Baiyun District
City Guangzhou
ZIP/Postal code 510407
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (2)
GSM4072337 Sham
GSM4072338 Tac
BioProject PRJNA564691
SRA SRP221182

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Supplementary file Size Download File type/resource
GSE137167_RAW.tar 148.2 Mb (http)(custom) TAR (of MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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