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Series GSE137024 Query DataSets for GSE137024
Status Public on Sep 07, 2019
Title Gene expression study in SF3B1-mutated, NOTCH1-mutated and WT CLL cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Mutations of SF3B1 in CLL induce alternative splicing in multiple transcripts, including DVL2. DVL2 in turn can act as a negative regulator of NOTCH1 signaling. Gene Expression Profile (GEP) was used to investigate the activation of the NOTCH1 pathway in presence of alternatively spliced DVL2.
Overall design Constitutive gene expression in CLL cells bearing either SF3B1 mutations, NOTCH1 mutation or none of them (WT). Bioinformatic analyses were performed by GenespringGX
Contributor(s) Pozzo F, Bomben R, Gattei V
Citation(s) 33121237
Submission date Sep 06, 2019
Last update date Jan 07, 2022
Contact name Federico Pozzo
Phone +390434659719
Organization name Centro di Riferimento Oncologico (CRO) di Aviano IRCCS
Department Department of Translational Research
Lab Clinical and Experimental Onco Hematology Unit
Street address via Franco Gallini 2
City Aviano
State/province PN
ZIP/Postal code 33081
Country Italy
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (28)
GSM4065840 CLL cells, 1326_NOTCH
GSM4065841 CLL cells, 2071_NOTCH
GSM4065842 CLL cells, 2495_SF3B1
BioProject PRJNA564296

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE137024_RAW.tar 207.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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