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| Status |
Public on Sep 04, 2020 |
| Title |
Radiation-Induced DNA Damage and Repair Effects on 3D Genome Organization |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
We investigate the impact of DNA damage response and repair on 3D genome folding using Hi-C experiments on wild type cells and ataxia telangiectasia mutated (ATM) patient cells. Fibroblasts, lymphoblasts, and ATM-deficient fibroblasts were irradiated with 5 Gy X-rays and Hi-C was performed after 30 minutes, 24 hours, or 5 days after irradiation.
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| Overall design |
Examination of the effects of X-rays on 6 different cell types
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| Contributor(s) |
Sanders JT, Freeman TF, Xu Y, Golloshi R, Stallard MA, Hill AM, Martin RS, Balajee A, McCord RP |
| Citation(s) |
33268790 |
| Submission date |
Sep 05, 2019 |
| Last update date |
Oct 03, 2021 |
| Contact name |
Rachel Patton McCord |
| E-mail(s) |
rmccord@utk.edu
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| Phone |
8659743149
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| Organization name |
University of Tennessee,Knoxville
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| Department |
BCMB
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| Street address |
1311 Cumberland Ave
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| City |
Knoxville |
| State/province |
TN |
| ZIP/Postal code |
37916 |
| Country |
USA |
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| Platforms (2) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA564008 |
| SRA |
SRP220427 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE136899_RAW.tar |
7.5 Gb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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