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Series GSE136682 Query DataSets for GSE136682
Status Public on Sep 16, 2019
Title Intestinal tumor expression data from Apcmin/+ mice gavaged by feces from healthy controls or colorectal cancer patients
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Colorectal cancer (CRC) is closely related to gut dysbiosis. We investigated the effects of imbalanced gut microbiota on the progression of intestinal adenoma in Apcmin/+ mice model using fecal microbiota transplantation (FMT). Administration of feces from CRC patients increased tumor proliferation and decreased apoptosis in tumor cells. Abnormal expression of genes related to Wnt-protein binding and lipid metabolic process was observed.
Overall design There were 7 mice in the RNA-seq, which include four in the FMT-AH group (gavage of fecal samples from healthy controls) and three in the FMT-AC group (gavage of fecal samples from patients with CRC).
Contributor(s) Wang B, Jiang K, Cao H, Li L, Li X
Citation(s) 31594750
Submission date Aug 30, 2019
Last update date Nov 18, 2019
Contact name Lu Li
Organization name General Hospital, Tianjin Medical University
Department Department of Gastroenterology and Hepatology
Street address 154 Anshan Road in Heping District
City Tianjin
ZIP/Postal code 300052
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (7)
GSM4055172 Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep1 [FMT_AH4]
GSM4055173 Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep2 [FMT_AH5]
GSM4055174 Intestinal tumor tissues of mice gavage with feces from healthy controls, biological rep3 [FMT_AH8]
BioProject PRJNA563056
SRA SRP219923

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Supplementary file Size Download File type/resource
GSE136682_all_gene_FPKM.txt.gz 2.7 Mb (ftp)(http) TXT
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Processed data are available on Series record

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